Interferon regulatory factor: Difference between revisions
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* '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors<ref>PMID:9488451</ref>.<br /> | * '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors<ref>PMID:9488451</ref>.<br /> | ||
* '''IRF-4''' is lymphoid-specific and functions in the development of immune cells<ref>PMID:23980171</ref>. | * '''IRF-4''' is lymphoid-specific and functions in the development of immune cells<ref>PMID:23980171</ref>. | ||
* '''IRF-9''' is a conductor of the cellular responses to interferons<ref>PMID:26987614</ref>. | |||
== Relevance == | == Relevance == | ||
Inhibition of IRF-5 may treat autoimmune diseases. Increased level of IRF-5 may help weak immune systems<ref>PMID:11846976</ref>. | Inhibition of IRF-5 may treat autoimmune diseases. Increased level of IRF-5 may help weak immune systems<ref>PMID:11846976</ref>. IRF-9 has a critical role in cerebral ischemic stroke<ref>PMID:25186738</ref>. | ||
== Disease == | == Disease == | ||
Deficiency in IRF-2 compromises development of natural killer cells and T helper cells<ref>PMID:10934221</ref>. | Deficiency in IRF-2 compromises development of natural killer cells and T helper cells<ref>PMID:10934221</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[3qu3]] - mIRF DNA binding domain | **[[3qu3]] - mIRF DNA binding domain | ||
*Interferon regulatory factor 9 | |||
**[[5oem]] – mIRF IAD domain<br /> | |||
**[[5oen]] – mIRF IAD domain + STAT2<br /> | |||
*Lytic viral interferon regulatory factor | |||
**[[4hlx]] – hvIRF DNA-binding domain - herpesvirus<br /> | |||
**[[4hly]] – hvIRF DNA-binding domain + DNA<br /> | |||
}} | }} | ||
== References == | == References == | ||