Intercellular adhesion molecule: Difference between revisions

Revision as of 13:26, 22 July 2018

Function

Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation^[1]. ICAM contains 5 Ig-like domains.

Disease

ICAM mutation is involved in multiple sclerosis^[2].

Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule3D structures of intercellular adhesion molecule

Updated on 22-July-2018

ReferencesReferences

↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767

[2] Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

[1]

[2]

@@ Line 25: / Line 25: @@
 **[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
 **[[3tcx]] – hICAM domain 1 + LFA-1<br />
+**[[6eit]] – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM<br />
 **[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
-**[[2qz4]] – hICAM domain 4 + antibody<br />
+**[[2oz4]] – hICAM domain 4 + antibody<br />
 **[[5mza]] – hICAM residues 28-212 + erythrocyte membrane protein 1<br />