6cta: Difference between revisions

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-'''Unreleased structure'''
-The entry 6cta is ON HOLD  until Paper Publication
+==Structure of the human cGAS-DNA complex with ATP==
+<StructureSection load='6cta' size='340' side='right' caption='[[6cta]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cta]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CTA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CTA FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cta OCA], [http://pdbe.org/6cta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cta RCSB], [http://www.ebi.ac.uk/pdbsum/6cta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cta ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cyclic GMP-AMP synthase]]
+[[Category: Kranzusch, P J]]
+[[Category: Mann, C C.de Oliveira]]
+[[Category: Mekalanos, J J]]
+[[Category: Morehouse, B R]]
+[[Category: Whiteley, A T]]
+[[Category: Zhou, W]]
+[[Category: Cga]]
+[[Category: Innate immunity]]
+[[Category: Sting]]
+[[Category: Transferase]]
+[[Category: Transferase-dna complex]]