6ay0: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ay0 is ON HOLD  until Paper Publication
+==Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide==
+<StructureSection load='6ay0' size='340' side='right' caption='[[6ay0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Maheshwari, S., Rudzka, K., Gabelli, S.B., Amzel, L.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ay0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY0 FirstGlance]. <br>
-Description: Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ay0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay0 OCA], [http://pdbe.org/6ay0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ay0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ay0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
+__TOC__
+</StructureSection>
+[[Category: Amzel, L M]]
+[[Category: Gabelli, S B]]
 [[Category: Maheshwari, S]]
 [[Category: Rudzka, K]]
-[[Category: Gabelli, S.B]]
+[[Category: Oxidoreductase]]
-[[Category: Amzel, L.M]]
+[[Category: Peptidylglycine 2-hydroxylase]]
+[[Category: Peptidylglycine monooxygenase]]
+[[Category: Phm]]