5y0d: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of the human nucleosome containing the H2B E76K mutant== | |||
<StructureSection load='5y0d' size='340' side='right' caption='[[5y0d]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5y0d]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y0D FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y0d OCA], [http://pdbe.org/5y0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y0d RCSB], [http://www.ebi.ac.uk/pdbsum/5y0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y0d ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arimura, Y]] | |||
[[Category: Fujita, R]] | |||
[[Category: Kurumizaka, H]] | |||
[[Category: Noda, M]] | |||
[[Category: Chromatin formation]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna binding protein-dna complex]] | |||
[[Category: Histone fold]] | |||
[[Category: Nucleosome]] | |||
[[Category: Nucleus]] | |||