2iwr: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Gtpase Like Domain Of Centaurin Gamma 1 (Human)== | ==Gtpase Like Domain Of Centaurin Gamma 1 (Human)== | ||
<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bmj|2bmj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bmj|2bmj]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
| Line 11: | Line 12: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwr_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwr_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 41: | Line 42: | ||
[[Category: Weigelt, J]] | [[Category: Weigelt, J]] | ||
[[Category: Yang, X]] | [[Category: Yang, X]] | ||
[[Category: Alternative splicing]] | |||
[[Category: Ank repeat]] | [[Category: Ank repeat]] | ||
[[Category: Centg1]] | [[Category: Centg1]] | ||
| Line 52: | Line 54: | ||
[[Category: Oncogene]] | [[Category: Oncogene]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Polymorphism]] | |||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Transport]] | [[Category: Transport]] | ||
[[Category: Zinc]] | |||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 10:07, 11 July 2018
Gtpase Like Domain Of Centaurin Gamma 1 (Human)Gtpase Like Domain Of Centaurin Gamma 1 (Human)
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedCentaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding studies, we show that, for CENTG1 (centaurin gamma-1) the GTPase-like domain has broader trinucleotide specificity. Alterations within the G4 motif of CENTG1 from the highly conserved NKXD found in typical GTPases to TQDR result in the loss of specificity, a lower affinity for the nucleotides and higher turnover rates. These results indicate that the centaurins could be more accurately classified as NTPases and point to alternative mechanisms of cell signalling control. The centaurin gamma-1 GTPase-like domain functions as an NTPase.,Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA Biochem J. 2007 Feb 1;401(3):679-88. PMID:17037982[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||||
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Human
- Arrowsmith, C
- Doyle, D A
- Edwards, A
- Elkins, J M
- Papagrigoriou, E
- Structural genomic
- Soundararajan, M
- Sundstrom, M
- Weigelt, J
- Yang, X
- Alternative splicing
- Ank repeat
- Centg1
- Gtp-binding
- Gtpase
- Gtpase activation
- Hydrolase
- Metal-binding
- Nuclear protein
- Nucleotide-binding
- Oncogene
- Phosphorylation
- Polymorphism
- Protein transport
- Sgc
- Transport
- Zinc
- Zinc-finger