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==Crystal structure of human mitochondrial ClpP complex with acyldepsipeptide ADEP-28== | |||
<StructureSection load='6bba' size='340' side='right' caption='[[6bba]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bba]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBA FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3A0:(2S,4S)-4-METHYLPIPERIDINE-2-CARBOXYLIC+ACID'>3A0</scene>, <scene name='pdbligand=ALO:ALLO-THREONINE'>ALO</scene>, <scene name='pdbligand=SHV:HEPTANOIC+ACID'>SHV</scene>, <scene name='pdbligand=WFP:3,5-DIFLUORO-L-PHENYLALANINE'>WFP</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bba OCA], [http://pdbe.org/6bba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bba RCSB], [http://www.ebi.ac.uk/pdbsum/6bba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bba ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLPP_HUMAN CLPP_HUMAN]] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Endopeptidase Clp]] | |||
[[Category: Houry, W A]] | |||
[[Category: Mabanglo, M F]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Mitochondria]] | |||
[[Category: Protease]] | |||
[[Category: Protein quality control]] | |||
[[Category: Proteostasis]] | |||
Revision as of 08:42, 11 July 2018
Crystal structure of human mitochondrial ClpP complex with acyldepsipeptide ADEP-28Crystal structure of human mitochondrial ClpP complex with acyldepsipeptide ADEP-28
Structural highlights
Function[CLPP_HUMAN] Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. |
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