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==Crystal structure of cysteine-bound ferrous form of the matured F2-Tyr157 human cysteine dioxygenase== | |||
<StructureSection load='6bpv' size='340' side='right' caption='[[6bpv]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bpv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BPV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=F2Y:3,5-DIFLUORO-L-TYROSINE'>F2Y</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_dioxygenase Cysteine dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.20 1.13.11.20] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpv OCA], [http://pdbe.org/6bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpv RCSB], [http://www.ebi.ac.uk/pdbsum/6bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CDO1_HUMAN CDO1_HUMAN]] Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cysteine dioxygenase]] | |||
[[Category: Li, J]] | [[Category: Li, J]] | ||
[[Category: Liu, A]] | [[Category: Liu, A]] | ||
[[Category: Shin, I]] | [[Category: Shin, I]] | ||
[[Category: Cys-tyr cofactor]] | |||
[[Category: Cysteine]] | |||
[[Category: Iron]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Unnatural amino acid]] | |||
Revision as of 10:11, 4 July 2018
Crystal structure of cysteine-bound ferrous form of the matured F2-Tyr157 human cysteine dioxygenaseCrystal structure of cysteine-bound ferrous form of the matured F2-Tyr157 human cysteine dioxygenase
Structural highlights
Function[CDO1_HUMAN] Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. |
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