2eox: Difference between revisions

Revision as of 12:12, 14 June 2018

Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473

Structural highlights

2eox is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	ZNF473 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002 Jan 1;16(1):58-71. PMID:11782445 doi:http://dx.doi.org/10.1101/gad.932302
↑ Wagner EJ, Marzluff WF. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006 Sep;26(17):6702-12. PMID:16914750 doi:http://dx.doi.org/26/17/6702
↑ Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA. 2006 Jul;12(7):1206-18. Epub 2006 May 18. PMID:16714279 doi:http://dx.doi.org/rna.2606

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002 Jan 1;16(1):58-71. PMID:11782445 doi:http://dx.doi.org/10.1101/gad.932302

[2] Wagner EJ, Marzluff WF. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006 Sep;26(17):6702-12. PMID:16914750 doi:http://dx.doi.org/26/17/6702

[3] Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA. 2006 Jul;12(7):1206-18. Epub 2006 May 18. PMID:16714279 doi:http://dx.doi.org/rna.2606

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
 ==Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473==
 <StructureSection load='2eox' size='340' side='right' caption='[[2eox]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eox OCA], [http://pdbe.org/2eox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eox RCSB], [http://www.ebi.ac.uk/pdbsum/2eox PDBsum], [http://www.topsan.org/Proteins/RSGI/2eox TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eox OCA], [http://pdbe.org/2eox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eox RCSB], [http://www.ebi.ac.uk/pdbsum/2eox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eox ProSAT], [http://www.topsan.org/Proteins/RSGI/2eox TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 13: / Line 14: @@
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eox_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eox_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>

2eox: Difference between revisions

Revision as of 12:12, 14 June 2018

Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473

Structural highlights

Function

Evolutionary Conservation

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

2eox: Difference between revisions

Revision as of 12:12, 14 June 2018

Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473Solution structure of the C2H2 type zinc finger (region 315-345) of human Zinc finger protein 473

Structural highlights

Function

Evolutionary Conservation

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search