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''' | {{Large structure}} | ||
==Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution== | |||
<StructureSection load='6g2h' size='340' side='right' caption='[[6g2h]], [[Resolution|resolution]] 4.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g2h]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2H FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2h OCA], [http://pdbe.org/6g2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2h RCSB], [http://www.ebi.ac.uk/pdbsum/6g2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2h ProSAT]</span></td></tr> | |||
</table> | |||
[[Category: | {{Large structure}} | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chami, M]] | |||
[[Category: Hagmann, A]] | |||
[[Category: Hunkeler, M]] | |||
[[Category: Maier, T]] | |||
[[Category: Stahlberg, H]] | |||
[[Category: Stuttfeld, E]] | |||
[[Category: Biotin-dependent carboxylase]] | |||
[[Category: Filament]] | |||
[[Category: Helical]] | |||
[[Category: Ligase]] | |||
[[Category: Multienzyme]] | |||
Revision as of 10:43, 14 June 2018
Warning: this is a large structure, and loading might take a long time or not happen at all.
Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolutionFilament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution
Structural highlights
Warning: this is a large structure, and loading might take a long time or not happen at all. Disease[ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.[1] Function[ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.[2] References
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