5o57: Difference between revisions
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==Solution Structure of the N-terminal Region of Dkk4== | |||
<StructureSection load='5o57' size='340' side='right' caption='[[5o57]], [[NMR_Ensembles_of_Models | 70 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5o57]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O57 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o57 OCA], [http://pdbe.org/5o57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o57 RCSB], [http://www.ebi.ac.uk/pdbsum/5o57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o57 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DKK4_HUMAN DKK4_HUMAN]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Barkell, A M]] | |||
[[Category: Carr, M D]] | |||
[[Category: Holdsworth, G]] | |||
[[Category: Muskett, F W]] | |||
[[Category: Patel, S]] | |||
[[Category: Robinson, M K]] | |||
[[Category: Waters, L C]] | |||
[[Category: Cysteine-rich domain 1]] | |||
[[Category: Dkk4]] | |||
[[Category: Signaling protein]] | |||
[[Category: Wnt signalling]] | |||
Revision as of 10:29, 14 June 2018
Solution Structure of the N-terminal Region of Dkk4Solution Structure of the N-terminal Region of Dkk4
Structural highlights
Function[DKK4_HUMAN] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
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