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==Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2== | ==Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2== | ||
<StructureSection load='2edi' size='340' side='right' caption='[[2edi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2edi' size='340' side='right' caption='[[2edi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
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<table><tr><td colspan='2'>[[2edi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDI FirstGlance]. <br> | <table><tr><td colspan='2'>[[2edi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDI FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edi OCA], [http://pdbe.org/2edi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edi RCSB], [http://www.ebi.ac.uk/pdbsum/2edi PDBsum], [http://www.topsan.org/Proteins/RSGI/2edi TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edi OCA], [http://pdbe.org/2edi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edi RCSB], [http://www.ebi.ac.uk/pdbsum/2edi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2edi ProSAT], [http://www.topsan.org/Proteins/RSGI/2edi TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edi_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edi_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 09:56, 6 June 2018
Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2
Structural highlights
Function[UBE2F_HUMAN] Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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