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Mutations in BRCA1/BARD1 RING-domain heterodimer: Difference between revisions

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  </jmolLink>
  </jmolLink>
</jmol> between the two states.   
</jmol> between the two states.   
*<scene name='75/751104/C39r/1'>Mutation C39R:</scene>  
*<scene name='75/751104/C39r/2'>Mutation C39R:</scene>  
<jmol>
<jmol>
  <jmolLink>
  <jmolLink>
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  </jmolLink>
  </jmolLink>
</jmol> between the two states. This mutation causes missing of S-Zn bond.
</jmol> between the two states. This mutation causes missing of S-Zn bond.
*<scene name='75/751104/H41r/5'>Mutation H41R:</scene>  
*<scene name='75/751104/H41r/6'>Mutation H41R:</scene>  
<jmol>
<jmol>
  <jmolLink>
  <jmolLink>
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  </jmolLink>
  </jmolLink>
</jmol> between the two states. This mutation causes missing of N-Zn bond.
</jmol> between the two states. This mutation causes missing of N-Zn bond.
*<scene name='75/751104/C44s/3'>Mutation C44S:</scene>  
*<scene name='75/751104/C44s/4'>Mutation C44S:</scene>  
<jmol>
<jmol>
  <jmolLink>
  <jmolLink>
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  </jmolLink>
  </jmolLink>
</jmol> between the two states. This mutation causes missing of S-Zn bond.
</jmol> between the two states. This mutation causes missing of S-Zn bond.
*<scene name='75/751104/C44y/3'>Mutation C44Y:</scene>  
*<scene name='75/751104/C44y/4'>Mutation C44Y:</scene>  
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=== Very severe pathogenic mutation ===
=== Very severe pathogenic mutation ===
*<scene name='75/751104/C61g/3'>Mutation C61G:</scene>  
*<scene name='75/751104/C61g/4'>Mutation C61G:</scene>  
<jmol>
<jmol>
  <jmolLink>
  <jmolLink>
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==Benign mutations==
==Benign mutations==
*<scene name='75/751104/Cv/26'>Mutation K45Q:</scene>
*<scene name='75/751104/Cv/29'>Mutation K45Q:</scene>
<jmol>
<jmol>
  <jmolLink>
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  </jmolLink>
  </jmolLink>
</jmol> between the two states.  
</jmol> between the two states.  
*<scene name='75/751104/Cv/27'>Mutation D67Y:</scene>  
*<scene name='75/751104/Cv/30'>Mutation D67Y:</scene>  
<jmol>
<jmol>
  <jmolLink>
  <jmolLink>

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Alexander Berchansky, Jaime Prilusky, Joel L. Sussman, Michal Harel
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