2d92: Difference between revisions

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==Solution structure of the fifth PDZ domain of InaD-like protein==
==Solution structure of the fifth PDZ domain of InaD-like protein==
<StructureSection load='2d92' size='340' side='right' caption='[[2d92]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2d92' size='340' side='right' caption='[[2d92]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<table><tr><td colspan='2'>[[2d92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D92 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2d92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D92 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INADL, PATJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INADL, PATJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d92 OCA], [http://pdbe.org/2d92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d92 RCSB], [http://www.ebi.ac.uk/pdbsum/2d92 PDBsum], [http://www.topsan.org/Proteins/RSGI/2d92 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d92 OCA], [http://pdbe.org/2d92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d92 RCSB], [http://www.ebi.ac.uk/pdbsum/2d92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d92 ProSAT], [http://www.topsan.org/Proteins/RSGI/2d92 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d92_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d92_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d92 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
== References ==

Revision as of 09:57, 30 May 2018

Solution structure of the fifth PDZ domain of InaD-like proteinSolution structure of the fifth PDZ domain of InaD-like protein

Structural highlights

2d92 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:INADL, PATJ (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[INADL_HUMAN] Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J Cell Biol. 2002 Apr 1;157(1):161-72. Epub 2002 Apr 1. PMID:11927608 doi:http://dx.doi.org/10.1083/jcb.200109010
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