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==Solution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from human== | ==Solution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from human== | ||
<StructureSection load='2da0' size='340' side='right' caption='[[2da0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2da0' size='340' side='right' caption='[[2da0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
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<table><tr><td colspan='2'>[[2da0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DA0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2da0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DA0 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2da0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da0 OCA], [http://pdbe.org/2da0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2da0 RCSB], [http://www.ebi.ac.uk/pdbsum/2da0 PDBsum], [http://www.topsan.org/Proteins/RSGI/2da0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2da0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da0 OCA], [http://pdbe.org/2da0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2da0 RCSB], [http://www.ebi.ac.uk/pdbsum/2da0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2da0 ProSAT], [http://www.topsan.org/Proteins/RSGI/2da0 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da0_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da0_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 09:26, 30 May 2018
Solution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from humanSolution structure of the PH domain of PIP2-dependent ARF1 GTPase-activating protein from human
Structural highlights
Function[ASAP1_HUMAN] Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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