Galectin: Difference between revisions
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== Function == | == Function == | ||
'''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD)<ref>PMID:8063692</ref>. <br /> | '''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD) residues 113-250<ref>PMID:8063692</ref>. <br /> | ||
* GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br /> | * GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br /> | ||
* GAL-2 is expressed primarily in gastrointestinal tract.<br /> | * GAL-2 is expressed primarily in gastrointestinal tract.<br /> | ||
* GAL-3 has broad biological functionality.<br /> | * GAL-3 has broad biological functionality.<br /> | ||
* GAL-4 has 2 CRDs.<br /> | * GAL-4 has 2 CRDs.<br /> | ||
* GAL-5 is found in rat is a β-galactoside binding lectin<ref>PMID:19903899</ref>.<br /> | |||
* GAL-7 is associated with epithelial cells.<br /> | * GAL-7 is associated with epithelial cells.<br /> | ||
* GAL-8 has a role in cellular defense against bacterial infection and vacuolar damage.<br /> | * GAL-8 has a role in cellular defense against bacterial infection and vacuolar damage.<br /> | ||
* GAL-9 affects eosinophil survival. <br /> | * GAL-9 affects eosinophil survival. <br /> | ||
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids. | * GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids.<br /> | ||
* GAL-13 is a placental protein which does not bind β-galactosides.<br /> | |||
== Relevance == | == Relevance == | ||
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**[[1w6o]], [[2zkn]] – hGAL-1 (mutant) + lactose<br /> | **[[1w6o]], [[2zkn]] – hGAL-1 (mutant) + lactose<br /> | ||
**[[4q26]], [[4q27]], [[4xbl]] - hGAL-1 + acetyl lactosamine<br /> | **[[4q26]], [[4q27]], [[4xbl]] - hGAL-1 + acetyl lactosamine<br /> | ||
**[[1w6p]] – hGAL-1 (mutant) + acetyl lactosamine<br /> | |||
**[[4y1u]], [[4y1v]], [[4y1x]], [[4y1y]], [[4y1z]], [[4y20]], [[4y22]], [[4y24]] - hGAL-1 N-terminal + Gal-GlcNac<br /> | **[[4y1u]], [[4y1v]], [[4y1x]], [[4y1y]], [[4y1z]], [[4y20]], [[4y22]], [[4y24]] - hGAL-1 N-terminal + Gal-GlcNac<br /> | ||
**[[1gzw]] – hGAL-1 + BGAL<br /> | **[[1gzw]] – hGAL-1 + BGAL<br /> | ||
**[[1w6m]] – hGAL(mutant) + BGAL<br /> | **[[1w6m]] – hGAL(mutant) + BGAL<br /> | ||
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**[[3oyw]] - hGAL-1 + thio-digalactoside<br /> | **[[3oyw]] - hGAL-1 + thio-digalactoside<br /> | ||
**[[3t2t]], [[4q1p]], [[4q1r]], [[4q2f]] – hGAL-1 + inhibitor<br /> | **[[3t2t]], [[4q1p]], [[4q1r]], [[4q2f]] – hGAL-1 + inhibitor<br /> | ||
**[[5mwt]], [[5mwx]] – hGAL-1 + ligand<br /> | |||
**[[1gan]] – tGAL-1 + BGAL – toad<br /> | **[[1gan]] – tGAL-1 + BGAL – toad<br /> | ||
**[[1a78]] – tGAL-1 + thio-digalactose<br /> | **[[1a78]] – tGAL-1 + thio-digalactose<br /> | ||
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*Galectin-3 | *Galectin-3 | ||
**[[3zsk]], [[3zsl]], [[3zsm]] – hGAL-3 CRD<br /> | **[[3zsk]], [[3zsl]], [[3zsm]], [[5nlc]] – hGAL-3 CRD<br /> | ||
**[[6f2q]] - hGAL-3 CRD – neutron<br /> | |||
**[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br /> | **[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br /> | ||
**[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br /> | **[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br /> | ||
**[[2nn8]], [[3aye]], [[3zsj]], [[4r9a]], [[4r9b]], [[4r9c]], [[4r9d]], [[4rl7]] - hGAL-3 CRD + lactose<br /> | **[[2nn8]], [[3aye]], [[3zsj]], [[4r9a]], [[4r9b]], [[4r9c]], [[4r9d]], [[4rl7]] - hGAL-3 CRD + lactose<br /> | ||
**[[1kjr ]], [[4xbn]] – hGAL-3 CRD + | **[[1kjr ]], [[4xbn]], [[5nf7]], [[5nf9]], [[5nla]], [[5nlb]] – hGAL-3 CRD + lactosamine derivative<br /> | ||
**[[2xg3]], [[3t1l]], [[3t1m]], [[5e88]], [[5e89]], [[5e8a]], [[5exo]], [[5h9p]], [[5h9r]], [[5iuq]] - hGAL-3 CRD + inhibitor<br /> | **[[2xg3]], [[3t1l]], [[3t1m]], [[5e88]], [[5e89]], [[5e8a]], [[5exo]], [[5h9p]], [[5h9r]], [[5iuq]] - hGAL-3 CRD + inhibitor<br /> | ||
**[[3aya]] - hGAL-3 CRD + antigen<br /> | **[[3aya]] - hGAL-3 CRD + antigen<br /> | ||
**[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]] - hGAL-3 CRD + polysaccharide<br /> | **[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]] - hGAL-3 CRD + polysaccharide<br /> | ||
**[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-3 CRD (mutant) + glycosphingolipid<br /> | **[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-3 CRD (mutant) + glycosphingolipid<br /> | ||
**[[4bli]], [[4blj]], [[4bm8]] - hGAL-3 CRD + thiogalactoside derivative<br /> | **[[4bli]], [[4blj]], [[4bm8]], [[5oax]], [[5ody]] - hGAL-3 CRD + thiogalactoside derivative<br /> | ||
*Galectin-4 | *Galectin-4 | ||
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**[[2dyc]] – mGAL-4 CRD <br /> | **[[2dyc]] – mGAL-4 CRD <br /> | ||
**[[3i8t]] – mGAL-4 + lactose<br /> | **[[3i8t]] – mGAL-4 + lactose<br /> | ||
*Galectin-5 | |||
**[[5jp5]] – rGAL-5<br /> | |||
**[[5jpg]] – rGAL-5 + lactose<br /> | |||
*Galectin-7 | *Galectin-7 | ||
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**[[5t7t]] – hGAL-8 N terminal (mutant) + LNT<br /> | **[[5t7t]] – hGAL-8 N terminal (mutant) + LNT<br /> | ||
**[[2yy1]] – hGAL-8 N terminal + acetyllactosamine<br /> | **[[2yy1]] – hGAL-8 N terminal + acetyllactosamine<br /> | ||
**[[5vwg]] – hGAL-8 N terminal (mutant) + galactopyranoside derivative<br /> | |||
**[[4wvv]], [[4wvw]] - cGAL-8 N terminal + lactose derivative<br /> | **[[4wvv]], [[4wvw]] - cGAL-8 N terminal + lactose derivative<br /> | ||
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**[[2d6p]] – mGAL-9 CRD + antigen<br /> | **[[2d6p]] – mGAL-9 CRD + antigen<br /> | ||
**[[3lsd]] – hGAL-9 N terminal<br /> | **[[3lsd]] – hGAL-9 N terminal<br /> | ||
**[[3wv6]] – hGAL (mutant)<br /> | **[[3wv6]] – hGAL-9 (mutant)<br /> | ||
**[[3nv1]] – hGAL-9 CRD<br /> | **[[3nv1]] – hGAL-9 CRD<br /> | ||
**[[3lse]] – hGAL-9 N terminal + lactose<br /> | **[[3lse]] – hGAL-9 N terminal + lactose<br /> | ||
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*Galectin-10 | *Galectin-10 | ||
**[[5xrg]], [[5xrh]] – hGAL-10 <br /> | |||
**[[5yt4]], [[5xri]], [[5xrj]], [[5xrk]], [[5xrl]], [[5xrm]], [[5xrn]], [[5xro]], [[5xrp]] – hGAL-10 (mutant)<br /> | |||
**[[1bkz]] – hGAL-10 + mannose<br /> | **[[1bkz]] – hGAL-10 + mannose<br /> | ||
**[[1hdk]] – hGAL-10 + PCMBS | **[[1hdk]] – hGAL-10 + PCMBS | ||
*Galectin-13 or galactoside-binding soluble lectin 13 | |||
**[[5xg7]] – hGAL-13 <br /> | |||
**[[5y03]], [[5xg9]] – hGAL-13 (mutant)<br /> | |||
*Galectin | *Galectin | ||
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**[[4hl0]], [[5glt]], [[5glu]], [[5glv]], [[5glw]], [[5glz]], [[5gm0]] – GAL – ''Toxascaris leonina''<br /> | **[[4hl0]], [[5glt]], [[5glu]], [[5glv]], [[5glw]], [[5glz]], [[5gm0]] – GAL – ''Toxascaris leonina''<br /> | ||
**[[3wuc]], [[3wud]] – GAL – ''Xenopus laevis''<br /> | **[[3wuc]], [[3wud]] – GAL – ''Xenopus laevis''<br /> | ||
**[[5nld]], [[5nle]], [[5nlh]], [[5nlz]], [[5nm1]], [[5nm6]], [[5nmj]] – cGAL + lactose<br /> | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||