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==Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5B)== | |||
<StructureSection load='2cdg' size='340' side='right' caption='[[2cdg]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2cdg' size='340' side='right' caption='[[2cdg]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2cdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDG FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b88|1b88]], [[1bwm|1bwm]], [[1h5b|1h5b]], [[1hxm|1hxm]], [[1ktk|1ktk]], [[1l0y|1l0y]], [[1tvd|1tvd]], [[2axh|2axh]], [[2axj|2axj]], [[2cde|2cde]], [[2cdf|2cdf]], [[1cd1|1cd1]], [[1ao7|1ao7]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1bd2|1bd2]], [[1lp9|1lp9]], [[1mi5|1mi5]], [[2bnq|2bnq]], [[2bnr|2bnr]], [[2bnu|2bnu]], [[1kgc|1kgc]], [[1fo0|1fo0]], [[1kj2|1kj2]], [[1nam|1nam]], [[2ckb|2ckb]], [[1g6r|1g6r]], [[1mwa|1mwa]], [[1kb5|1kb5]], [[1nfd|1nfd]], [[1tcr|1tcr]], [[1fyt|1fyt]], [[1j8h|1j8h]], [[1d9k|1d9k]], [[1ymm|1ymm]], [[1ypz|1ypz]], [[1zt4|1zt4]], [[1z5l|1z5l]], [[1zhn|1zhn]], [[2akr|2akr]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b88|1b88]], [[1bwm|1bwm]], [[1h5b|1h5b]], [[1hxm|1hxm]], [[1ktk|1ktk]], [[1l0y|1l0y]], [[1tvd|1tvd]], [[2axh|2axh]], [[2axj|2axj]], [[2cde|2cde]], [[2cdf|2cdf]], [[1cd1|1cd1]], [[1ao7|1ao7]], [[1qrn|1qrn]], [[1qse|1qse]], [[1qsf|1qsf]], [[1bd2|1bd2]], [[1lp9|1lp9]], [[1mi5|1mi5]], [[2bnq|2bnq]], [[2bnr|2bnr]], [[2bnu|2bnu]], [[1kgc|1kgc]], [[1fo0|1fo0]], [[1kj2|1kj2]], [[1nam|1nam]], [[2ckb|2ckb]], [[1g6r|1g6r]], [[1mwa|1mwa]], [[1kb5|1kb5]], [[1nfd|1nfd]], [[1tcr|1tcr]], [[1fyt|1fyt]], [[1j8h|1j8h]], [[1d9k|1d9k]], [[1ymm|1ymm]], [[1ypz|1ypz]], [[1zt4|1zt4]], [[1z5l|1z5l]], [[1zhn|1zhn]], [[2akr|2akr]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdg OCA], [http://pdbe.org/2cdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdg RCSB], [http://www.ebi.ac.uk/pdbsum/2cdg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdg OCA], [http://pdbe.org/2cdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdg RCSB], [http://www.ebi.ac.uk/pdbsum/2cdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
| Line 10: | Line 11: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdg_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdg_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 11:47, 23 May 2018
Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5B)Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5B)
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedInvariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha chains. The results were similar to those previously reported for MHC-peptide-specific TCRs, illustrating the versatility of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided plausible insights into their interaction. The model supports a diagonal orientation of TCR on CD1d and suggests that complementarity determining region (CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d, whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer. Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.,Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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