2c6z: Difference between revisions
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== | |||
==crystal structure of dimethylarginine dimethylaminohydrolase I in complex with citrulline== | |||
<StructureSection load='2c6z' size='340' side='right' caption='[[2c6z]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='2c6z' size='340' side='right' caption='[[2c6z]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ci1|2ci1]], [[2ci3|2ci3]], [[2ci4|2ci4]], [[2ci5|2ci5]], [[2ci6|2ci6]], [[2ci7|2ci7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ci1|2ci1]], [[2ci3|2ci3]], [[2ci4|2ci4]], [[2ci5|2ci5]], [[2ci6|2ci6]], [[2ci7|2ci7]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6z OCA], [http://pdbe.org/2c6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c6z RCSB], [http://www.ebi.ac.uk/pdbsum/2c6z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6z OCA], [http://pdbe.org/2c6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c6z RCSB], [http://www.ebi.ac.uk/pdbsum/2c6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c6z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6z_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6z_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2c6z" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2c6z" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Dimethylarginine Dimethylaminohydrolase|Dimethylarginine Dimethylaminohydrolase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Grutter, M G]] | [[Category: Grutter, M G]] | ||
[[Category: Vasak, M]] | [[Category: Vasak, M]] | ||
[[Category: Acetylation]] | |||
[[Category: Adma]] | [[Category: Adma]] | ||
[[Category: Ddah i]] | [[Category: Ddah i]] | ||
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[[Category: No]] | [[Category: No]] | ||
[[Category: S-nitrosylation]] | [[Category: S-nitrosylation]] | ||
[[Category: Zinc]] | |||
Revision as of 10:56, 23 May 2018
crystal structure of dimethylarginine dimethylaminohydrolase I in complex with citrullinecrystal structure of dimethylarginine dimethylaminohydrolase I in complex with citrulline
Structural highlights
Function[DDAH1_BOVIN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedDimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS. Here, we present high-resolution crystal structures of DDAH isoform 1 (DDAH-1) isolated from bovine brain in complex with different inhibitors, including S-nitroso-L-homocysteine and Zn2+, a regulator of this mammalian enzyme. The structure of DDAH-1 consists of a propeller-like fold similar to other arginine-modifying enzymes and a flexible loop, which adopts different conformations and acts as a lid at the entrance of the active site. The orientation and interaction mode of inhibitors in the active site give insight into the regulation and the molecular mechanism of the enzyme. The presented structures provide a basis for the structure-based development of specific DDAH-1 inhibitors that might be useful in the therapeutic treatment of NOS dysfunction-related diseases. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors.,Frey D, Braun O, Briand C, Vasak M, Grutter MG Structure. 2006 May;14(5):901-11. PMID:16698551[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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