5nnc: Difference between revisions

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-'''Unreleased structure'''
-The entry 5nnc is ON HOLD
+==Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)==
+<StructureSection load='5nnc' size='340' side='right' caption='[[5nnc]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
-Authors: Filippakopoulos, P., Picaud, S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nnc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNC FirstGlance]. <br>
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnc OCA], [http://pdbe.org/5nnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnc RCSB], [http://www.ebi.ac.uk/pdbsum/5nnc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnc ProSAT]</span></td></tr>
-[[Category: Pike, A.C.W]]
+</table>
-[[Category: Arrowsmith, C.H]]
+== Disease ==
-[[Category: Von Delft, F]]
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A M]]
+[[Category: Filippakopoulos, P]]
 [[Category: Picaud, S]]
-[[Category: Filippakopoulos, P]]
+[[Category: Pike, A C.W]]
-[[Category: Edwards, A.M]]
+[[Category: Bromodomain]]
-[[Category: Bountra, C]]
+[[Category: Complex]]
+[[Category: Transcription]]