5wnk: Difference between revisions

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'''Unreleased structure'''


The entry 5wnk is ON HOLD until Paper Publication
==Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115==
 
<StructureSection load='5wnk' size='340' side='right' caption='[[5wnk]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5wnk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNK FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6J:3,3-(2,4-diaminopteridine-6,7-diyl)diphenol'>B6J</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wni|5wni]], [[5wnj|5wnj]], [[5wnl|5wnl]], [[5wnm|5wnm]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wnk OCA], [http://pdbe.org/5wnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wnk RCSB], [http://www.ebi.ac.uk/pdbsum/5wnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wnk ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RIPK4_MOUSE RIPK4_MOUSE]] Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.<ref>PMID:12446564</ref> <ref>PMID:22197488</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Huang, C S]]
[[Category: Hymowitz, S G]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 09:13, 9 May 2018

Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115

Structural highlights

5wnk is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RIPK4_MOUSE] Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.[1] [2]

References

  1. ↑ Meylan E, Martinon F, Thome M, Gschwendt M, Tschopp J. RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep. 2002 Dec;3(12):1201-8. doi: 10.1093/embo-reports/kvf236. Epub 2002 Nov , 21. PMID:12446564 doi:http://dx.doi.org/10.1093/embo-reports/kvf236
  2. ↑ Mitchell K, O'Sullivan J, Missero C, Blair E, Richardson R, Anderson B, Antonini D, Murray JC, Shanske AL, Schutte BC, Romano RA, Sinha S, Bhaskar SS, Black GC, Dixon J, Dixon MJ. Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Am J Hum Genet. 2012 Jan 13;90(1):69-75. doi: 10.1016/j.ajhg.2011.11.013. Epub, 2011 Dec 22. PMID:22197488 doi:10.1016/j.ajhg.2011.11.013

5wnk, resolution 3.11Å

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