Elizeu/sandbox/citocromo c: Difference between revisions

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Mati Cohen, Student, Joel L. Sussman, Urs Leisinger, Gauri Misra, Abhinav Mittal, Noam Gonen, Brooke Fenn, Vesta Nwankwo, Shai Biran, Anna Lohning, Keni Vidilaseris, Shira Weingarten-Gabbay, Brett M. Thumm, Elizabeth A. Dunlap, Brian Ochoa, Jamie Costa, Edmond R Atalla, Katherine Reynolds, Julie Langlois, Madison Walberry, Rebecca Holstein, Dotan Shaniv, Elizeu Santos, Gulalai Shah, Idan Ben-Nachum, Atena Farhangian

Revision as of 06:33, 6 May 2018 view source Atena Farhangian (talk \| contribs) 67 edits No edit summary ← Older edit		Latest revision as of 06:34, 6 May 2018 view source Atena Farhangian (talk \| contribs) 67 edits No edit summary
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	Ramachandran plot analysis shows that most non-glycine residues are located in the most favorable regions. There is only one exception to this, which is Lys251, (apo-AlgQ1, φ=65° and ψ=-141°; holo-AlgQ1-TE, φ=62° and ψ=-133°; and holo-AlgQ1-DI (1Y3N), φ=65° and ψ=-139°), and it is present in an allowed region. Lys251 is located next to the terminus of a helix (H12/C)<ref>PMID:15794643</ref>.		Ramachandran plot analysis shows that most non-glycine residues are located in the most favorable regions. There is only one exception to this, which is Lys251, (apo-AlgQ1, φ=65° and ψ=-141°; holo-AlgQ1-TE, φ=62° and ψ=-133°; and holo-AlgQ1-DI (1Y3N), φ=65° and ψ=-139°), and it is present in an allowed region. Lys251 is located next to the terminus of a helix (H12/C)<ref>PMID:15794643</ref>.

	The crystal structure of AlgQ2 consist of two domains separated by a cleft and binds and releases alginate tetrasaccharide by creating conformational change in these two domains<ref>PMID:21326935</ref>. To mention some of the different forms of this protein we can take a look at 5H6U, 5H71, 1KWH, 1J1N in PDB.~~The~~ As an alginate binding protein, the dissociation constants are 6 μg/mL for AlgQ1 and 4 μg/mL for AlgQ2.Results from UV absorption spectroscopy indicate that both of these proteins are alginate specific<ref>PMID:15794643</ref>.		The crystal structure of AlgQ2 consist of two domains separated by a cleft and binds and releases alginate tetrasaccharide by creating conformational change in these two domains<ref>PMID:21326935</ref>. To mention some of the different forms of this protein we can take a look at 5H6U, 5H71, 1KWH, 1J1N in PDB. As an alginate binding protein, the dissociation constants are 6 μg/mL for AlgQ1 and 4 μg/mL for AlgQ2.Results from UV absorption spectroscopy indicate that both of these proteins are alginate specific<ref>PMID:15794643</ref>.