User:Andrea Foote/Sandbox 1: Difference between revisions
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== Tissue Specificity == | == Tissue Specificity == | ||
While Purα is a ubiquitously expressed protein in all cell types, it is generally found at low levels in most tissues. However, in adult humans and mice Purα expression is highest in the brain and spinal cord, and to a lesser extent in the testes. Purα has been shown to be upregulated in cardiac myocyte gap junctions following heart transplant in mice, colocalizing with SMαA.<ref>PMID:18344281</ref> | While Purα is a ubiquitously expressed protein in all cell types, it is generally found at low levels in most tissues. However, in adult humans and mice Purα expression is highest in the brain and spinal cord, and to a lesser extent in the testes. Purα has been shown to be upregulated in cardiac myocyte gap junctions following heart transplant in mice, colocalizing with SMαA.<ref>PMID:18344281</ref> | ||
== Interactions == | |||
Purα is known to interact with: | |||
• Purβ | |||
• Serum response factor (SRF) | |||
• Y-box-binding protein 1 (YB-1) (MSY1 in mice) | |||
• Retinoblastoma protein (RB) | |||
• Rm62 RNA helicase of HIV | |||
== Disease == | == Disease == | ||