User:Andrea Foote/Sandbox 1: Difference between revisions

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== Introduction ==

'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to ~~recognize and~~ bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, ~~including cousins~~ Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ~~____~~. It plays a crucial role in nervous system development, and ~~additionally is known to be involved in cell cycle regulation. Mutations~~ in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).

'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to bind sequence-specific purine-rich regions of ssDNA and ssRNA, specifically GGN repeats. Purα is a member of the PUR family of proteins, which includes Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) encoded by the ''Acta2'' gene. It is also known to be involved in DNA replication and cell cycle regulation as well as mRNA translation. It plays a crucial role in nervous system development, and mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).

== Structure ==

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 <StructureSection load='5fgp' size='340' side='right' caption='''Drosophila Purα intramolecular domain (purple: PUR repeat I, orange: PUR repeat II) in complex with DNA (green). X-ray diffraction, 2Å resolution ([[5fgp]]).''' scene='78/786627/5fgp_intro/8'>
 == Introduction ==
-'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to recognize and bind sequence-specific purine-rich regions of ssDNA and ssRNA. Purα is a member of the PUR family of proteins, including cousins Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) and ____. It plays a crucial role in nervous system development, and additionally is known to be involved in cell cycle regulation. Mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).
+'''Purine-rich element binding protein alpha''' (Purα or PurA) is a transcription factor with a molecular weight of ~35 kDa encoded by the PURA gene. It is known to bind sequence-specific purine-rich regions of ssDNA and ssRNA, specifically GGN repeats. Purα is a member of the PUR family of proteins, which includes Purβ and two isoforms of Purγ. In its functional dimeric form Purα is known to repress expression of smooth muscle alpha actin (SMαA) encoded by the ''Acta2'' gene. It is also known to be involved in DNA replication and cell cycle regulation as well as mRNA translation. It plays a crucial role in nervous system development, and mutations in Purα have been implicated in two neurological diseases: PURA syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) (see Disease section).
 == Structure ==