Alpha-lytic protease: Difference between revisions

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'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease.  The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease.  The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
*<scene name='55/551214/Cv/2'>ALP protease domain and pro domain complex with benzenesulfonyl fluoride</scene>.
*<scene name='55/551214/Cv/2'>ALP protease domain and pro domain complex with benzenesulfonyl fluoride</scene>.
*<scene name='55/551214/Cv/3'>Benzenesulfonyl fluoride binding site</scene> (PDB entry [[3pro]]).<ref>PMID:9808037</ref>
*<scene name='55/551214/Cv/3'>Benzenesulfonyl fluoride binding site</scene> (PDB entry [[3pro]]).<ref>PMID:9808037</ref> Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>


Revision as of 14:43, 2 May 2018


Alpha-lytic protease (ALP) is a bacterial serine protease of the chymotrypsin family. ALP is a two-domain enzyme. One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease. The second domain is the protease domain (residues 200-397).[1]

  • .
  • (PDB entry 3pro).[2] Water molecules are shown as red spheres.

Structure of alpha-lytic protease protease domain (green) and pro domain (magenta) complex with benzenesulfonyl fluoride (PDB entry 3pro)

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3D Structures of alpha-lytic protease3D Structures of alpha-lytic protease

Updated on 02-May-2018

ReferencesReferences

  1. ↑ Bone R, Frank D, Kettner CA, Agard DA. Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry. 1989 Sep 19;28(19):7600-9. PMID:2611204
  2. ↑ Sauter NK, Mau T, Rader SD, Agard DA. Structure of alpha-lytic protease complexed with its pro region. Nat Struct Biol. 1998 Nov;5(11):945-50. PMID:9808037 doi:http://dx.doi.org/10.1038/2919

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Michal Harel, Alexander Berchansky
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