1zax: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B== | ==Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B== | ||
<StructureSection load='1zax' size='340' side='right' caption='[[1zax]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1zax' size='340' side='right' caption='[[1zax]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zav|1zav]], [[1zaw|1zaw]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zav|1zav]], [[1zaw|1zaw]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rplJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589]), rplL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rplJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589]), rplL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zax OCA], [http://pdbe.org/1zax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zax RCSB], [http://www.ebi.ac.uk/pdbsum/1zax PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zax OCA], [http://pdbe.org/1zax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zax RCSB], [http://www.ebi.ac.uk/pdbsum/1zax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zax ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 13: | Line 14: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zax_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zax_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 28: | Line 29: | ||
</div> | </div> | ||
<div class="pdbe-citations 1zax" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1zax" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 12:17, 2 May 2018
Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form BRibosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B
Structural highlights
Function[RL10_THEMA] Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3) (Probable).[HAMAP-Rule:MF_00362] [RL7_THEMA] Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify these elements in cryo-electron-microscopic reconstructions of Escherichia coli ribosomes. The mobile C-terminal helix alpha8 of L10 carries three L7/12 dimers in T. maritima and two in E. coli, in concordance with the different length of helix alpha8 of L10 in these organisms. The stalk is organized into three elements (stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex, and L7/12 C-terminal domains) linked by flexible connections. Highly mobile L7/12 C-terminal domains promote recruitment of translation factors to the ribosome and stimulate GTP hydrolysis by the ribosome bound factors through stabilization of their active GTPase conformation. Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation.,Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC Cell. 2005 Jul 1;121(7):991-1004. PMID:15989950[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||||
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Atcc 43589
- Diaconu, M
- Fischer, N
- Harms, J M
- Kothe, U
- Rodnina, M V
- Schluenzen, F
- Stark, H
- Tonevitski, A G
- Wahl, M C
- Gtpase stimulation
- L10-l12 complex structure
- L10e structure
- L7/12 ribosomal stalk
- Mechanism of translation
- Rapid kinetic
- Ribosome structure and function
- Structural protein
- Thiostrepton loop of 23s rrna
- Translation factor recruitment