6eiu: Difference between revisions

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-'''Unreleased structure'''
-The entry 6eiu is ON HOLD  until Mar 19 2019
+==Crystal structure of KDM5B in complex with KDOPZ29a==
+<StructureSection load='6eiu' size='340' side='right' caption='[[6eiu]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
-Authors: Srikannathasan, V., Newman, J.A., Szykowska, A., Wright, M., Ruda, G.F., Vazquez-Rodriguez, S.A., Kupinska, K., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Huber, K., von Delft, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6eiu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIU FirstGlance]. <br>
-Description: Crystal structure of KDM5B in complex with KDOPZ29a
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6T:8-oxidanyl-6-phenyl-7-propan-2-yl-imidazo[1,2-b]pyridazine-3-carbonitrile'>B6T</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eiu OCA], [http://pdbe.org/6eiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eiu RCSB], [http://www.ebi.ac.uk/pdbsum/6eiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eiu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N A]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A]]
 [[Category: Huber, K]]
-[[Category: Ruda, G.F]]
+[[Category: Kupinska, K]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Newman, J A]]
 [[Category: Oppermann, U]]
+[[Category: Ruda, G F]]
+[[Category: Srikannathasan, V]]
+[[Category: Strain-Damerell, C]]
 [[Category: Szykowska, A]]
-[[Category: Burgess-Brown, N.A]]
+[[Category: Vazquez-Rodriguez, S A]]
-[[Category: Von Delft, F]]
-[[Category: Vazquez-Rodriguez, S.A]]
-[[Category: Newman, J.A]]
-[[Category: Edwards, A]]
-[[Category: Strain-Damerell, C]]
 [[Category: Wright, M]]
-[[Category: Srikannathasan, V]]
+[[Category: Kdm5b lysine specific demethylase]]
-[[Category: Bountra, C]]
+[[Category: Oxidoreductase]]
-[[Category: Kupinska, K]]