5xi3: Difference between revisions

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-'''Unreleased structure'''
-The entry 5xi3 is ON HOLD  until May 03 2019
+==BRD4 bound with compound Bdi3==
+<StructureSection load='5xi3' size='340' side='right' caption='[[5xi3]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
-Authors: Xiong, B., Cao, D., Li, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xi3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XI3 FirstGlance]. <br>
-Description: BRD4 bound with compound Bdi3
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8F6:(3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{R})-1-phenylethyl]amino]-3~{H}-quinoxalin-2-one'>8F6</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi3 OCA], [http://pdbe.org/5xi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi3 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Cao, D]]
+[[Category: Li, Y]]
 [[Category: Xiong, B]]
-[[Category: Li, Y]]
+[[Category: Chromatin regulator]]
+[[Category: Transcription-inhibitor complex]]