5xi2: Difference between revisions

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'''Unreleased structure'''


The entry 5xi2 is ON HOLD  until May 03 2019
==BRD4 bound with compound Bdi2==
 
<StructureSection load='5xi2' size='340' side='right' caption='[[5xi2]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
Authors: Xiong, B., Cao, D., Li, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5xi2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XI2 FirstGlance]. <br>
Description: BRD4 bound with compound Bdi2
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8F9:(3~{R})-4-cyclopropyl-1,3-dimethyl-6-[[(1~{S})-1-(4-methylphenyl)ethyl]amino]-3~{H}-quinoxalin-2-one'>8F9</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi2 OCA], [http://pdbe.org/5xi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi2 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi2 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cao, D]]
[[Category: Cao, D]]
[[Category: Li, Y]]
[[Category: Xiong, B]]
[[Category: Xiong, B]]
[[Category: Li, Y]]
[[Category: Chromatin regulator]]
[[Category: Transcription-inhibitor complex]]

Revision as of 11:03, 2 May 2018

BRD4 bound with compound Bdi2BRD4 bound with compound Bdi2

Structural highlights

5xi2 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

5xi2, resolution 1.91Å

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OCA
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