User:Tanner Young/Sandbox 1: Difference between revisions

Revision as of 22:07, 30 April 2018 view source Tanner Young (talk \| contribs) 23 edits No edit summary ← Older edit		Revision as of 22:23, 30 April 2018 view source Tanner Young (talk \| contribs) 23 edits No edit summary Newer edit →
Line 1:		Line 1:
	==Structure==		==Structure==

	<scene name='78/786030/Pten_molecule/1'>PTEN</scene> is a protein that consists of 403-amino acids. Breaking it down into two main parts (the C-terminal and the N-terminal) it has 166 residues on the C-terminal (C2 Domain) and 179 on the N-terminal (Phosphatase Domain). PTEN is consisted of Alpha helix and Beta pleated sheets.		<scene name='78/786030/Pten_molecule/1'>PTEN</scene> is a protein that consists of 403-amino acids. Breaking it down into two main parts (the C-terminal and the N-terminal) it has 166 residues on the C-terminal (C2 Domain) and 179 on the N-terminal (Phosphatase Domain). PTEN is consisted of Alpha helix and Beta pleated sheets. PTEN has a signature motif that forms a Walker loop (Phosphate-bonding loop) HCXXGXXR which is residues 123-130. The pocket of PTEN is about 8 angstroms deep. There are Cys, Arg, His, and Gly within the Walker loop. His and Gly are both important for the Walker loop, while the Cys and Arg are important for the catalytic ability of the PTEN enzyme. One difference from PTEN compared to other know Protein Tyrosine Phosphatases (PTPs) is the location of two Lys residues in the center of the Walker Loop