6ft4: Difference between revisions

Revision as of 08:52, 18 April 2018

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Structural highlights

6ft4 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.^[1] ^[2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

[1] French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779

[2] French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ft4 is ON HOLD
+==Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand==
+<StructureSection load='6ft4' size='340' side='right' caption='[[6ft4]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
-Authors: Filippakopoulos, P., Picaud, S., Pike, A.C.W., Krojer, T., Conway, S.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ft4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FT4 FirstGlance]. <br>
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E5W:3-[[4,4-bis(fluoranyl)piperidin-1-yl]methyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)phenol'>E5W</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ft4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ft4 OCA], [http://pdbe.org/6ft4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ft4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ft4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ft4 ProSAT]</span></td></tr>
-[[Category: Pike, A.C.W]]
+</table>
-[[Category: Arrowsmith, C.H]]
+== Disease ==
-[[Category: Von Delft, F]]
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-[[Category: Picaud, S]]
+== Function ==
-[[Category: Conway, S.J]]
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Conway, S J]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A M]]
 [[Category: Filippakopoulos, P]]
-[[Category: Edwards, A.M]]
 [[Category: Krojer, T]]
-[[Category: Bountra, C]]
+[[Category: Picaud, S]]
+[[Category: Pike, A C.W]]
+[[Category: Bromodomain]]
+[[Category: Isoxazole]]
+[[Category: Ligand]]
+[[Category: Transcription]]

6ft4: Difference between revisions

Revision as of 08:52, 18 April 2018

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Structural highlights

Disease

Function

References

Contents

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6ft4: Difference between revisions

Revision as of 08:52, 18 April 2018

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Structural highlights

Disease

Function

References

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Navigation menu

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