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==Crystal structure of the gastric proton pump complexed with vonoprazan== | |||
<StructureSection load='5ylu' size='340' side='right' caption='[[5ylu]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ylu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YLU FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE1:O-DODECANYL+OCTAETHYLENE+GLYCOL'>CE1</scene>, <scene name='pdbligand=HKT:1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine'>HKT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ylu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ylu OCA], [http://pdbe.org/5ylu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ylu RCSB], [http://www.ebi.ac.uk/pdbsum/5ylu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ylu ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hydrogen/potassium-exchanging ATPase]] | |||
[[Category: Abe, K]] | |||
[[Category: Fujiyoshi, Y]] | |||
[[Category: Irie, K]] | |||
[[Category: Nakanishi, H]] | |||
[[Category: Gastric]] | |||
[[Category: H+]] | |||
[[Category: K+-atpase]] | |||
[[Category: Membrane protein]] | |||
[[Category: P-type atpase]] | |||
[[Category: Proton pump]] | |||
[[Category: Transporter]] | |||
Revision as of 16:48, 11 April 2018
Crystal structure of the gastric proton pump complexed with vonoprazanCrystal structure of the gastric proton pump complexed with vonoprazan
Structural highlights
Disease[ATP4B_PIG] Note=Parietal cell autoantigen associated with autoimmune gastritis. Function[ATP4A_PIG] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. |
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