Vpr protein: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Elia Shlush

@@ Line 20: / Line 20: @@
 == Conservation ==
-Vpr is <scene name='75/750237/Conservation/3'>highly conserved</scene> in HIV and  simian immunodeficiency virus (SIV), similar retrovirus which infects non-human primates<ref name='Morellet2003'/>. In addition, all primate lentiviruses has Vpr gene whose protein product has highly conserved motifs. HIV-2 and SIVsm lentiviruses have additionally gene - Vpx. In these lentiviruses, Vpr and Vpx executes together the roles which HIV-1 Vpr perform. Vpr and Vpx has low conservation between them<ref name='Emerman1996'/>. However, Vpr and Vpx families of proteins use related structural regions to bind and recruit cellular targets to the E3 ligase complex for degradation by the proteasome<ref name='Wu2016'/>.<br/>
+Vpr is <scene name='75/750237/Conservation/3'>highly conserved</scene> in HIV and  simian immunodeficiency virus (SIV), similar retrovirus which infects non-human primates<ref name='Morellet2003'/>. In addition, all primate lentiviruses has Vpr gene whose protein product has highly conserved motifs. HIV-2 and SIVsm lentiviruses have additionally gene - ''vpx''. In these lentiviruses, Vpr and Vpx executes together the roles which HIV-1 Vpr perform. Vpr and Vpx has low conservation between them<ref name='Emerman1996'/>. However, Vpr and Vpx families of proteins use related structural regions to bind and recruit cellular targets to the E3 ligase complex for degradation by the proteasome<ref name='Wu2016'/>.<br/>
 [[Image:Consurf_key_small.gif|200px|right]]