Cadherin: Difference between revisions

Revision as of 09:41, 4 April 2018

Function

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains:
*Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.^[1]

Desmogleins (Des-CDH) are CDH found in desmosomes.

Structural highlights

The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by docking into the hydrophobic pocket of the neighboring CDH molecule. ^[2]

3D Structures of Cadherin3D Structures of Cadherin

Updated on 04-April-2018

CDH5
- 2koh – mCDH5+PAR3-PDZ3 - mouse
CDH6
- 3lnd – mCDH6 EC12 (mutant)
CDH8
- 1zxk – mCDH8 EC1
- 2a62 - mCDH8 EC1-EC3
CDH11
- 2a4c, 2a4e – mCDH11 EC1
CDH20
- 1zvn – cCDH20 EC1 – chicken
CDH23
- 3mvs, 2whv – mCDH23 N-terminal
- 2kbr – hCDH23 peptide+harmonin – NMR - human
- 2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
- 2wbx – mCDH23 EC1
- 2wcp - mCDH23 EC2
- 2wd0 - mCDH23 EC1-EC2 (mutant)
- 5tfm - mCDH23 EC6-EC8
- 5tfl - mCDH23 EC7-EC8
- 5tfk - mCDH23 EC19-EC21
- 5i8d, 5ulu, 5un2 - mCDH23 EC19-EC21 (mutant)
- 5uz8 - mCDH23 EC22-EC24
- 4apx, 4aq8, 4axw, 4xxw - mCDH23 EC1-EC2 + Prot-CDH15
- 4aqa, 4aqe - mCDH23 EC1-EC2 (mutant) + Prot-CDH15
C-CDH “classical”
- 1l3w – XlC-CDH ectodomain - Xenopus laevis
- 1q5b, 1q5c, 1q55, 1q5a – C-CDH model into desmosome – electron tomography
E-CDH epithelial or CDH1
- 1q1p, 1ff5, 1edh, 3lne, 3lnf, 3lng, 3lnh, 3lni, 2qvf – mE-CDH EC1-EC2
- 3q2v – mE-CDH ectodomain
- 4zt1, 2o72 – hE-CDH EC1-EC2
- 4zte – hE-CDH EC1-EC2 + inhibitor
- 1edh - mE-CDH EC1-EC2+Ca
- 3q2l, 3q2n, 3qrb - mE-CDH EC1-EC2 (mutant)
- 1suh – mE-CDH N-terminal - NMR
- 1i7x, 1i7w – mE-CDH cytoplasmic domain +catenin
- 4qd2 – mE-CDH + botulinum neurotoxin
- 3ifq – hE-CDH EC1-EC3
- 3ff7, 3ff8 - hE-CDH EC1-EC3+NK cell receptor
- 2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
- 1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes
- 4qd2 – mE-CDH + botulinum neurotoxin
K-CDH kidney or CDH6
- 5veb – hK-CDH EC5 + antibody
T-CDH membrane bound
- 3k5r – mT-CDH EC1-EC2
- 3k5s - cT-CDH EC1-EC2
- 3k6d - XlT-CDH EC1
- 3k6f - mT-CDH EC1
- 3k6i - cT-CDH EC1
- 2v37 – hT-CDH N-terminal - NMR
N-CDH neuronal
- 1nch, 1nci – mN-CDH
- 1ncg – mN-CDH (mutant)
- 2qvi, 4nuq – mN-CDH EC1-EC2
- 4num, 4nup – mN-CDH EC1-EC2 (mutant)
- 1ncj – mN-CDH two domains
- 3q2w – mN-CDH ectodomain
- 1op4 - mN-CDH prodomain - NMR
- 3ubf – DmN-CDH ectodomain – Drosophila melanogaster
- 3ubh - DmN-CDH EC1-EC4
- 3ubg - DmN-CDH EC1-EC3
P-CDH placental or CDH3
- 4nqq – mP-CDH EC1-EC2
- 4oy9, 4zml, 4zmn, 4zmq, 4zmt, 4zmw, 4zmz – hP-CDH EC1-EC2
- 4zmo, 4zmp, 4zmv, 4zmx, 4zmy – hP-CDH EC1-EC2 (mutant)
- 5jyl, 5jym – hP-CDH EC1-EC2 + SCFV TSP7
VE-CDH vascular epithelial
- 3ppe – cVE-CDH EC1+EC2
Protocadherin
- 2yst – hProt-CDH7 EC3 – NMR
- 2ee0 - hProt-CDH9 Ca domain – NMR
- 1wyj - mProt-CDH β 14 - NMR
- 1wuz - mProt-CDH4 EC1 – NMR
- 5cyx - mProt-CDH2 EC1+EC2+EC3
Desmoglein
- 2yqg – hDes-CDH2 EC1
- 5erd – hDes-CDH2 ectodomain
- 5eqx – hDes-CDH3 ectodomain
Desmocollin
- 5iry – hDesmc1 ectodomain
- 5erp, 5j5j – hDesmc2 ectodomain

ReferencesReferences

↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368

[2] Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

[1]

[2]

@@ Line 3: / Line 3: @@
 == Function ==
-[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.   Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental).  The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
+[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.   Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney).  The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
 *'''Desmogleins''' (Des-CDH) are CDH found in desmosomes.
@@ Line 28: / Line 28: @@
 **[[1zxk]] – mCDH8 EC1<br />
-**[[2a62]] - mCDH8 EC1+EC2+EC3<br />
+**[[2a62]] - mCDH8 EC1-EC3<br />
 * CDH11
@@ Line 45: / Line 45: @@
 **[[2wbx]] – mCDH23 EC1<br />
 **[[2wcp]] - mCDH23 EC2<br />
-**[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
+**[[2wd0]] - mCDH23 EC1-EC2 (mutant)<br />
-**[[4apx]], [[4aq8]], [[4axw]], [[4xxw]] - mCDH23 EC1+EC2 + Prot-CDH15<br />
+**[[5tfm]] - mCDH23 EC6-EC8<br />
-**[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
+**[[5tfl]] - mCDH23 EC7-EC8<br />
+**[[5tfk]] - mCDH23 EC19-EC21<br />
+**[[5i8d]], [[5ulu]], [[5un2]] - mCDH23 EC19-EC21 (mutant)<br />
+**[[5uz8]] - mCDH23 EC22-EC24<br />
+**[[4apx]], [[4aq8]], [[4axw]], [[4xxw]] - mCDH23 EC1-EC2 + Prot-CDH15<br />
+**[[4aqa]], [[4aqe]] - mCDH23 EC1-EC2 (mutant) + Prot-CDH15
 * C-CDH “classical”
@@ Line 56: / Line 61: @@
 * E-CDH epithelial or CDH1
-**[[1q1p]], [[1ff5]], [[1edh]], [[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]], [[2qvf]] – mE-CDH EC1+EC2<br />
+**[[1q1p]], [[1ff5]], [[1edh]], [[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]], [[2qvf]] – mE-CDH EC1-EC2<br />
 **[[3q2v]] – mE-CDH ectodomain<br />
-**[[4zt1]], [[2o72]] – hE-CDH EC1+EC2<br />
+**[[4zt1]], [[2o72]] – hE-CDH EC1-EC2<br />
-**[[1edh]] - mE-CDH EC1+EC2+Ca<br />
+**[[4zte]] – hE-CDH EC1-EC2 + inhibitor<br />
-**[[3q2l]], [[3q2n]], [[3qrb]] - mE-CDH EC1+EC2 (mutant)<br />
+**[[1edh]] - mE-CDH EC1-EC2+Ca<br />
+**[[3q2l]], [[3q2n]], [[3qrb]] - mE-CDH EC1-EC2 (mutant)<br />
 **[[1suh]] – mE-CDH N-terminal - NMR<br />
 **[[1i7x]], [[1i7w]] – mE-CDH cytoplasmic domain +catenin<br />
 **[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
-**[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
+**[[3ifq]] – hE-CDH EC1-EC3 <br />
-**[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
+**[[3ff7]], [[3ff8]] - hE-CDH EC1-EC3+NK cell receptor<br />
 **[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
 **[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
 **[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
+*K-CDH kidney or CDH6
+**[[5veb]] – hK-CDH EC5 + antibody<br />
 * T-CDH membrane bound
-**[[3k5r]] – mT-CDH EC1+EC2<br />
+**[[3k5r]] – mT-CDH EC1-EC2<br />
-**[[3k5s]] - cT-CDH EC1+EC2 <br />
+**[[3k5s]] - cT-CDH EC1-EC2 <br />
 **[[3k6d]] - XlT-CDH EC1 <br />
 **[[3k6f]] - mT-CDH EC1<br />
@@ Line 89: / Line 99: @@
 **[[1op4]] - mN-CDH prodomain - NMR<br />
 **[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
-**[[3ubh]] - DmN-CDH EC1-4<br />
+**[[3ubh]] - DmN-CDH EC1-EC4<br />
-**[[3ubg]] - DmN-CDH EC1-3
+**[[3ubg]] - DmN-CDH EC1-EC3
 *P-CDH placental or CDH3
-**[[4nqq]] – mP-CDH EC1+EC2<br />
+**[[4nqq]] – mP-CDH EC1-EC2<br />
-**[[4oy9]], [[4zml]], [[4zmn]], [[4zmq]], [[4zmt]], [[4zmw]], [[4zmz]] – hP-CDH EC1+EC2<br />
+**[[4oy9]], [[4zml]], [[4zmn]], [[4zmq]], [[4zmt]], [[4zmw]], [[4zmz]] – hP-CDH EC1-EC2<br />
-**[[4zmo]], [[4zmp]], [[4zmv]], [[4zmx]], [[4zmy]] – hP-CDH EC1+EC2 (mutant)<br />
+**[[4zmo]], [[4zmp]], [[4zmv]], [[4zmx]], [[4zmy]] – hP-CDH EC1-EC2 (mutant)<br />
-**[[5jyl]], [[5jym]] – hP-CDH EC1+EC2 + SCFV TSP7<br />
+**[[5jyl]], [[5jym]] – hP-CDH EC1-EC2 + SCFV TSP7<br />
 *VE-CDH vascular epithelial