ATP-citrate synthase: Difference between revisions

Revision as of 15:07, 22 March 2018

Function

ATP-citrate synthase (ACS) is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.

Structural highlights

Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. of ATP-citrate synthase. , 3pff. ^[1]

ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), 3pff

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3D Structures of ATP-citrate synthase3D Structures of ATP-citrate synthase

Updated on 22-March-2018

3mwd, 5tde – hACS + citrate – human
5tdf, 5tet – hACS + citrate derivative
5teq – hACS N-terminal (mutant) + citrate
5te1 – hACS N-terminal (mutant) + citrate derivative
5tes – hACS + citrate + ADP
5tdm – hACS + citrate derivative + ADP
3mwe – hACS + tartrate
3pff, 5tdz - hACS + tartrate + ADP

ReferencesReferences

↑ Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363

[1]

@@ Line 16: / Line 16: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[3mwd]] – hACS + citrate – human<br />
+[[3mwd]], [[5tde]] – hACS + citrate – human<br />
+[[5tdf]], [[5tet]] – hACS + citrate derivative<br />
+[[5teq]] – hACS N-terminal (mutant) + citrate <br />
+[[5te1]] – hACS N-terminal (mutant) + citrate derivative<br />
+[[5tes]] – hACS + citrate + ADP<br />
+[[5tdm]] – hACS + citrate derivative + ADP<br />
 [[3mwe]] – hACS + tartrate<br />
-[[3pff]] - hACS + tartrate + ADP
+[[3pff]], [[5tdz]] - hACS + tartrate + ADP<br />
 == References ==
 <references/>
 [[Category:Topic Page]]