6cbx: Difference between revisions

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-'''Unreleased structure'''
-The entry 6cbx is ON HOLD
+==Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497==
+<StructureSection load='6cbx' size='340' side='right' caption='[[6cbx]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
-Authors: ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CBX FirstGlance]. <br>
-Description: Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EW1:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone'>EW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbx OCA], [http://pdbe.org/6cbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cbx RCSB], [http://www.ebi.ac.uk/pdbsum/6cbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: BROWN, P J]]
+[[Category: Bountra, C]]
+[[Category: Casimiro-Garcia, A]]
+[[Category: DONG, A]]
+[[Category: Edwards, A M]]
 [[Category: Hutchinson, A]]
-[[Category: Arrowsmith, C.H]]
+[[Category: KUMPF, R]]
+[[Category: OWEN, A]]
+[[Category: Structural genomic]]
 [[Category: Seitova, A]]
-[[Category: Dong, A]]
+[[Category: TATLOCK, J]]
-[[Category: Brown, P.J]]
+[[Category: TAYLOR, A]]
-[[Category: Casimiro-Garcia, A]]
+[[Category: WU, H]]
-[[Category: Zeng, H]]
+[[Category: ZENG, H]]
-[[Category: Taylor, A]]
+[[Category: Sgc]]
-[[Category: Tatlock, J]]
+[[Category: Smyd2 mtf9975 inhibitor]]
-[[Category: Owen, A]]
+[[Category: Transferase-inhibitor complex]]
-[[Category: Edwards, A.M]]
-[[Category: Kumpf, R]]
-[[Category: Structural Genomics Consortium (Sgc)]]
-[[Category: Wu, H]]
-[[Category: Bountra, C]]