5laq: Difference between revisions

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'''Unreleased structure'''


The entry 5laq is ON HOLD  until Paper Publication
==Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001==
 
<StructureSection load='5laq' size='340' side='right' caption='[[5laq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Singh, A.K., Brown, D.G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5laq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LAQ FirstGlance]. <br>
Description: Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6M5:(4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one'>6M5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g57|5g57]], [[5g2b|5g2b]], [[5l8c|5l8c]], [[5l9h|5l9h]], [[5g5v|5g5v]], [[5l8y|5l8y]]</td></tr>
[[Category: Brown, D.G]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5laq OCA], [http://pdbe.org/5laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5laq RCSB], [http://www.ebi.ac.uk/pdbsum/5laq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5laq ProSAT]</span></td></tr>
[[Category: Singh, A.K]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Brown, D G]]
[[Category: Singh, A K]]
[[Category: Alternative splicing]]
[[Category: Camp]]
[[Category: Hydrolase]]
[[Category: Phosphodiesterase]]

Revision as of 09:17, 14 March 2018

Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001

Structural highlights

5laq is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]

References

  1. ↑ Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
  2. ↑ Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040

5laq, resolution 2.40Å

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