2fk0: Difference between revisions
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|PDB= 2fk0 |SIZE=350|CAPTION= <scene name='initialview01'>2fk0</scene>, resolution 2.95Å | |PDB= 2fk0 |SIZE=350|CAPTION= <scene name='initialview01'>2fk0</scene>, resolution 2.95Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fk0 OCA], [http://www.ebi.ac.uk/pdbsum/2fk0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fk0 RCSB]</span> | |||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
2FK0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | 2FK0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FK0 OCA]. | ||
==Reference== | ==Reference== | ||
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16543414 16543414] | Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16543414 16543414] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Viruses]] | |||
[[Category: Stevens, J.]] | [[Category: Stevens, J.]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
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[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:03:47 2008'' | ||
Revision as of 03:03, 31 March 2008
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| , resolution 2.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a H5N1 influenza virus hemagglutinin.
OverviewOverview
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
About this StructureAbout this Structure
2FK0 is a Protein complex structure of sequences from Viruses. Full crystallographic information is available from OCA.
ReferenceReference
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:16543414
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