6caa: Difference between revisions
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The entry | ==CryoEM structure of human SLC4A4 sodium-coupled acid-base transporter NBCe1== | ||
<StructureSection load='6caa' size='340' side='right' caption='[[6caa]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6caa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAA FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6caa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6caa OCA], [http://pdbe.org/6caa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6caa RCSB], [http://www.ebi.ac.uk/pdbsum/6caa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6caa ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/S4A4_HUMAN S4A4_HUMAN]] Autosomal recessive proximal renal tubular acidosis. The disease is caused by mutations affecting the gene represented in this entry. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/S4A4_HUMAN S4A4_HUMAN]] Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.<ref>PMID:10069984</ref> <ref>PMID:12907161</ref> <ref>PMID:16636648</ref> <ref>PMID:16769890</ref> <ref>PMID:17661077</ref> <ref>PMID:9235899</ref> <ref>PMID:9651366</ref> Isoform 2: May have a higher activity than isoform 1.<ref>PMID:16769890</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Abuladze, N]] | |||
[[Category: Azimov, R]] | |||
[[Category: Huynh, K W]] | |||
[[Category: Jiang, J]] | |||
[[Category: Kao, L]] | |||
[[Category: Kurtz, I]] | |||
[[Category: Newman, D]] | |||
[[Category: Pushkin, A]] | |||
[[Category: Shao, X]] | |||
[[Category: Tsirulnikov, K]] | |||
[[Category: Zhou, Z H]] | |||
[[Category: Electrogenic sodium-coupled bicarbonate cotransporter]] | |||
[[Category: Nbce1]] | |||
[[Category: Slc4a4]] | |||
[[Category: Transport protein]] | |||