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==HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor== | |||
<StructureSection load='5oym' size='340' side='right' caption='[[5oym]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5oym]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OYM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oym OCA], [http://pdbe.org/5oym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oym RCSB], [http://www.ebi.ac.uk/pdbsum/5oym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oym ProSAT]</span></td></tr> | |||
[[ | </table> | ||
[[Category: Carr, S | == Disease == | ||
[[http://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Carr, S B]] | |||
[[Category: Cruz-Migoni, A]] | |||
[[Category: Hannon, C]] | [[Category: Hannon, C]] | ||
[[Category: Rabbitts, T | [[Category: Phillips, S E.V]] | ||
[[Category: | [[Category: Rabbitts, T H]] | ||
[[Category: | [[Category: Domain swap]] | ||
[[Category: Integrase binding]] | |||
[[Category: Transciptional co-activator]] | |||
[[Category: Transcription]] | |||
Revision as of 08:00, 8 March 2018
HIV Integrase Binding Domain of Lens Epithelium-Derived Growth FactorHIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor
Structural highlights
Disease[PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. Function[PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.[1] References
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