2f9v: Difference between revisions
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|PDB= 2f9v |SIZE=350|CAPTION= <scene name='initialview01'>2f9v</scene>, resolution 2.60Å | |PDB= 2f9v |SIZE=350|CAPTION= <scene name='initialview01'>2f9v</scene>, resolution 2.60Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=BN6:(2S,8R,9S,15S)-15-CYCLOHEXYL-9,12-BIS(CYCLOPROPYLMETHYL)-8-HYDROXY-20-METHYL-4,7,11,14,17-PENTAOXO-2-PHENYL-18-OXA-3,6,10,12,13,16-HEXAAZAHENICOSAN-1-OIC+ACID'>BN6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NS3 protease domain ( residues 1027-1207 of the polyprotein). ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus]) | |GENE= NS3 protease domain ( residues 1027-1207 of the polyprotein). ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1a1r|1A1R]], [[1jxp|1JXP]], [[2a4g|2A4G]], [[2a4q|2A4Q]], [[2a4r|2A4R]], [[1n1l|1N1L]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9v OCA], [http://www.ebi.ac.uk/pdbsum/2f9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f9v RCSB]</span> | |||
}} | }} | ||
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[[Category: Ruan, S.]] | [[Category: Ruan, S.]] | ||
[[Category: Saksena, A.]] | [[Category: Saksena, A.]] | ||
[[Category: hcv]] | [[Category: hcv]] | ||
[[Category: hepatitis c protease]] | [[Category: hepatitis c protease]] | ||
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[[Category: ns3 protease]] | [[Category: ns3 protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:57 2008'' | ||
Revision as of 02:59, 31 March 2008
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | NS3 protease domain ( residues 1027-1207 of the polyprotein). (Hepatitis C virus) | ||||||
| Related: | 1A1R, 1JXP, 2A4G, 2A4Q, 2A4R, 1N1L
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
OverviewOverview
Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay.
About this StructureAbout this Structure
2F9V is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
ReferenceReference
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:16387495
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