6bli: Difference between revisions
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==RSV G peptide bound to Fab CB002.5== | |||
<StructureSection load='6bli' size='340' side='right' caption='[[6bli]], [[Resolution|resolution]] 2.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bli]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLI FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bli OCA], [http://pdbe.org/6bli PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bli RCSB], [http://www.ebi.ac.uk/pdbsum/6bli PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bli ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLYC_HRSV6 GLYC_HRSV6]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity). Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Jones, H G]] | |||
[[Category: Langedijk, J P]] | |||
[[Category: McLellan, J S]] | |||
[[Category: Antibody]] | |||
[[Category: Viral attachment protein]] | |||
[[Category: Viral protein]] | |||
[[Category: Viral protein-immune system complex]] | |||
Revision as of 09:32, 28 February 2018
RSV G peptide bound to Fab CB002.5RSV G peptide bound to Fab CB002.5
Structural highlights
Function[GLYC_HRSV6] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity). Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. |
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