5ydr: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ydr is ON HOLD
+==Structure of DNMT1 RFTS domain in complex with ubiquitin==
+<StructureSection load='5ydr' size='340' side='right' caption='[[5ydr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Qian, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ydr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YDR FirstGlance]. <br>
-Description: DNA methylation maintenance complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ydr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ydr OCA], [http://pdbe.org/5ydr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ydr RCSB], [http://www.ebi.ac.uk/pdbsum/5ydr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ydr ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN]] Defects in DNMT1 are the cause of hereditary sensory neuropathy type 1E (HSN1E) [MIM:[http://omim.org/entry/614116 614116]]. A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.<ref>PMID:21532572</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/DNMT1_HUMAN DNMT1_HUMAN]] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:16357870</ref> <ref>PMID:18754681</ref> <ref>PMID:18413740</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Qian, C]]
+[[Category: Dna methylation]]
+[[Category: Protein binding]]
+[[Category: Protein binding-transferase complex]]