User:Jaime.Prilusky/Test/Sortable: Difference between revisions
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'''Behind the Artwork and the Protein Structure''' | |||
The artist who created this image is Anna Valchanova, a student at Stephen Perse School in Cambridge, UK. She has presented the protein inside a drop of blood to reflect the blood transmission of the disease, and depicted the protein structure in bleach to reflect the decline of health once infected with Ebola virus. Anna has based her work on the GP ‘fusion loop’ structure, solved by NMR spectroscopy in the Tamm lab, in the University of Virginia, School of Medicine. Further information about this structure can be found in PDB entry [[2m5f]] <ref>pmid 24696482</ref> | |||
'''Ebola Virus''' | |||
The Ebola virus is a member of the family Filoviridae that form filamentous infectious virions, and encode their genome in single-stranded RNA. Ebola virus can be transmitted from wild animals to humans and also spreads through human-to-human transmission. To infect a host cell, the membrane of the virus fuses with that of the host, then the contents of the virus - its genome and proteins - enter the cell. After infection and replication in the host cell, the virus’ emerge from the cell, the surface of the virus is then formed from a membrane which is taken from the host cell. While the membrane might contain many host cell proteins, the only Ebola protein on the surface of the virus is one known as glycoprotein, or GP. | |||
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Revision as of 13:38, 16 February 2018
Behind the Artwork and the Protein Structure
The artist who created this image is Anna Valchanova, a student at Stephen Perse School in Cambridge, UK. She has presented the protein inside a drop of blood to reflect the blood transmission of the disease, and depicted the protein structure in bleach to reflect the decline of health once infected with Ebola virus. Anna has based her work on the GP ‘fusion loop’ structure, solved by NMR spectroscopy in the Tamm lab, in the University of Virginia, School of Medicine. Further information about this structure can be found in PDB entry 2m5f [1]
Ebola Virus
The Ebola virus is a member of the family Filoviridae that form filamentous infectious virions, and encode their genome in single-stranded RNA. Ebola virus can be transmitted from wild animals to humans and also spreads through human-to-human transmission. To infect a host cell, the membrane of the virus fuses with that of the host, then the contents of the virus - its genome and proteins - enter the cell. After infection and replication in the host cell, the virus’ emerge from the cell, the surface of the virus is then formed from a membrane which is taken from the host cell. While the membrane might contain many host cell proteins, the only Ebola protein on the surface of the virus is one known as glycoprotein, or GP.