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==STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND==
==STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND==
<StructureSection load='1om4' size='340' side='right' caption='[[1om4]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='1om4' size='340' side='right' caption='[[1om4]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOS1 OR BNOS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOS1 OR BNOS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1om4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1om4 OCA], [http://pdbe.org/1om4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1om4 RCSB], [http://www.ebi.ac.uk/pdbsum/1om4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1om4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1om4 OCA], [http://pdbe.org/1om4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1om4 RCSB], [http://www.ebi.ac.uk/pdbsum/1om4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1om4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/1om4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/1om4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1om4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1om4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Revision as of 10:38, 15 February 2018

STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUNDSTRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND

Structural highlights

1om4 is a 2 chain structure with sequence from Buffalo rat. The January 2011 RCSB PDB Molecule of the Month feature on Nitric Oxide Synthase by David Goodsell is 10.2210/rcsb_pdb/mom_2011_1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Gene:NOS1 OR BNOS (Buffalo rat)
Activity:Nitric-oxide synthase (NADPH dependent), with EC number 1.14.13.39
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1om4, resolution 1.75Å

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