6ffx: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ffx is ON HOLD  until Paper Publication
+==Crystal structure of R. ruber ADH-A, mutant F43H==
+<StructureSection load='6ffx' size='340' side='right' caption='[[6ffx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ffx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFX FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffx OCA], [http://pdbe.org/6ffx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffx RCSB], [http://www.ebi.ac.uk/pdbsum/6ffx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffx ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Laboratory evolution of alcohol dehydrogenase produced enzyme variants with improved turnover numbers with a vicinal 1,2-diol and its corresponding hydroxyketone. Crystal structure and transient kinetics analysis aids in rationalizing the new functions of these variants.
-Authors: Dobritzsch, D., Maurer, D., Hamnevik, E., Enugala, T.R., Widersten, M.
+Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin.,Hamnevik E, Maurer D, Enugala TR, Chu T, Lofgren R, Dobritzsch D, Widersten M Biochemistry. 2018 Feb 2. doi: 10.1021/acs.biochem.8b00055. PMID:29384657<ref>PMID:29384657</ref>
-Description: Crystal structure of R. ruber ADH-A, mutant F43H
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6ffx" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Dobritzsch, D]]
+[[Category: Enugala, T R]]
 [[Category: Hamnevik, E]]
+[[Category: Maurer, D]]
 [[Category: Widersten, M]]
-[[Category: Enugala, T.R]]
+[[Category: Alcohol dehydrogenase mutant variant]]
-[[Category: Maurer, D]]
+[[Category: Nadh-dependent]]
+[[Category: Oxidoreductase]]
+[[Category: Rossmann fold]]
+[[Category: Zn2+-dependent]]