5x3v: Difference between revisions

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'''Unreleased structure'''


The entry 5x3v is ON HOLD until Paper Publication
==Structure of human SHMT2 protein mutant==
 
<StructureSection load='5x3v' size='340' side='right' caption='[[5x3v]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5x3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X3V FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x3v OCA], [http://pdbe.org/5x3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x3v RCSB], [http://www.ebi.ac.uk/pdbsum/5x3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x3v ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GLYM_HUMAN GLYM_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.<ref>PMID:21876188</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Glycine hydroxymethyltransferase]]
[[Category: Li, J]]
[[Category: Sheng, J]]
[[Category: Serine hydroxymethyltransferase]]
[[Category: Transferase]]

Revision as of 09:29, 15 February 2018

Structure of human SHMT2 protein mutantStructure of human SHMT2 protein mutant

Structural highlights

5x3v is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Glycine hydroxymethyltransferase, with EC number 2.1.2.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GLYM_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.[1]

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

5x3v, resolution 2.85Å

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