5o3e: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "5o3e" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5o3e is ON HOLD
==Human Brd2(BD2) mutant in complex with Me-Am1==
 
<StructureSection load='5o3e' size='340' side='right' caption='[[5o3e]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
Authors: Chan, K.-H., Runcie, A.C., Ciulli, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5o3e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O3E FirstGlance]. <br>
Description: Human Brd2(BD2) mutant in complex with Me-Am1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9HW:(2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-~{N}-ethyl-propanamide'>9HW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DQW:(2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol'>DQW</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o3e OCA], [http://pdbe.org/5o3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o3e RCSB], [http://www.ebi.ac.uk/pdbsum/5o3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o3e ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chan, K H]]
[[Category: Ciulli, A]]
[[Category: Ciulli, A]]
[[Category: Chan, K.-H]]
[[Category: Runcie, A C]]
[[Category: Runcie, A.C]]
[[Category: Transcription]]

Revision as of 09:25, 15 February 2018

Human Brd2(BD2) mutant in complex with Me-Am1Human Brd2(BD2) mutant in complex with Me-Am1

Structural highlights

5o3e is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

References

  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

5o3e, resolution 1.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5o3e&oldid=2858433"