5o38: Difference between revisions

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'''Unreleased structure'''


The entry 5o38 is ON HOLD
==Human Brd2(BD2) mutant in free form==
 
<StructureSection load='5o38' size='340' side='right' caption='[[5o38]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5o38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O38 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9JB:3-[(2~{R})-2-oxidanylpropoxy]-2-[[(2~{R})-2-oxidanylpropoxy]methyl]-2-[[(2~{S})-2-oxidanylpropoxy]methyl]propan-1-ol'>9JB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DQW:(2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol'>DQW</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o38 OCA], [http://pdbe.org/5o38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o38 RCSB], [http://www.ebi.ac.uk/pdbsum/5o38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o38 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chan, K H]]
[[Category: Ciulli, A]]
[[Category: Runcie, A C]]
[[Category: Transcription]]

Revision as of 09:24, 15 February 2018

Human Brd2(BD2) mutant in free formHuman Brd2(BD2) mutant in free form

Structural highlights

5o38 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

References

  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

5o38, resolution 1.20Å

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OCA
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