5nsd: Difference between revisions

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-'''Unreleased structure'''
-The entry 5nsd is ON HOLD
+==Co-crystal structure of NAMPT dimer with KPT-9274==
+<StructureSection load='5nsd' size='340' side='right' caption='[[5nsd]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-Authors: Neggers, J.E., Kwanten, B., Dierckx, T., Noguchi, H., Voet, A., Vercruysse, T., Baloglu, E., Senapedis, W., Jacquemyn, M., Daelemans, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nsd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NSD FirstGlance]. <br>
-Description: NAMPT-1 with inhibitor bound
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=96Q:(~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide'>96Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nsd OCA], [http://pdbe.org/5nsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nsd RCSB], [http://www.ebi.ac.uk/pdbsum/5nsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nsd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Baloglu, E]]
+[[Category: Daelemans, D]]
+[[Category: Dierckx, T]]
+[[Category: Jacquemyn, M]]
+[[Category: Kwanten, B]]
+[[Category: Neggers, J E]]
+[[Category: Noguchi, H]]
 [[Category: Senapedis, W]]
-[[Category: Noguchi, H]]
-[[Category: Kwanten, B]]
 [[Category: Vercruysse, T]]
 [[Category: Voet, A]]
-[[Category: Jacquemyn, M]]
+[[Category: Crispr/ca]]
-[[Category: Neggers, J.E]]
+[[Category: Drug target]]
-[[Category: Baloglu, E]]
+[[Category: Nampt]]
-[[Category: Daelemans, D]]
+[[Category: Transferase]]
-[[Category: Dierckx, T]]