5mwt: Difference between revisions

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'''Unreleased structure'''


The entry 5mwt is ON HOLD
==Galectin-1 in Complex with Ligand JB97==
 
<StructureSection load='5mwt' size='340' side='right' caption='[[5mwt]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
Authors: Grimm, C., Bechold, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5mwt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MWT FirstGlance]. <br>
Description: Galectin-1 in Complex with Ligand JB97
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=JB9:~{N}-[(2~{R},3~{R},4~{R},5~{S},6~{R})-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-4-[[1-[[3-[(~{Z})-3-[bis(azanyl)methylideneamino]prop-1-enyl]phenyl]methyl]-1,2,3-triazol-4-yl]methoxy]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-6-(hydroxymethyl)-4-oxidanyl-2-prop-2-enoxy-oxan-3-yl]ethanamide'>JB9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mwt OCA], [http://pdbe.org/5mwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mwt RCSB], [http://www.ebi.ac.uk/pdbsum/5mwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mwt ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bechold, J]]
[[Category: Grimm, C]]
[[Category: Grimm, C]]
[[Category: Bechold, J]]
[[Category: Bifidobacterium]]
[[Category: Bisp]]
[[Category: Sucrose phosphorylase]]
[[Category: Transferase]]

Revision as of 09:22, 15 February 2018

Galectin-1 in Complex with Ligand JB97Galectin-1 in Complex with Ligand JB97

Structural highlights

5mwt is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.[1] [2]

References

  1. ↑ He J, Baum LG. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 6;279(6):4705-12. Epub 2003 Nov 14. PMID:14617626 doi:10.1074/jbc.M311183200
  2. ↑ Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008 Dec;18(12):1065-73. Epub 2008 Sep 16. PMID:18796645 doi:10.1093/glycob/cwn089

5mwt, resolution 1.71Å

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